Here's another entrant in the growing field of hotel booking sites. As I'm sure you know there's a number around and the competition is meaning that each participant is having to raise his game: to the great benefit of us consumers, of course.
This site, EasyToBook, is certainly easy to navigate around...in fact the whole process is really very easy to use indeed. They're also not reginally bound: they offer the opportunity to book all around the world. Here's their London hotels page, their Prague hotels page and their hotels in Barcelona page.
They also go into quite some detail about the individual hotels. Here's the write up on a New York hotel and here's another one on a hotel in Dublin.
All in all it looks like a very useful site and it certainly is very easy to use, as they promise.